Researching the hydrodynamic characteristics of artificial reef in wave-current is very important for the design of artificial reef. Based on the finite volume method, adopting the velocity border as a wave generator, a multifunctional 3D-numerical wave-current tank was established by the volume of fluid (VOF) method, which can simulate the hydrodynamic characteristics of the artificial reef under the action of wave, current and wave-current, respectively. Based on this numerical model, the hydrodynamic characteristics of the cylindrical hollow artificial reef under different actions of wave-current was investigated. Compared the numerical results with experimental results，the accuracy of the simulation of forces was verified．The results show that the maximum of the wave-current force of artificial reefs increases with the increase of wave height, period and flow velocity. The simulation results also show that when the artificial reef is directly below the crest of the wave field, the area of wake vortex of the artificial reef increases with the increase of flow velocity, but decreases with the increase of wave height and period. By comparing the hydrodynamic characteristics of artificial reefs under the action of single homogeneous flow, single wave and wave-current, the maximum wave-current force of the artificial reef is greater than the maximum wave force and the water flow force. The simulation results also show that the flow field effect under wave-current interaction is the largest, and a large-scale vortex structure is formed at the rear of the reef.