With the decline of marine fishing output, the deterioration of the coastal ecosystem and the continually growing demand for healthy and environmentally friendly seafood, the marine aquaculture has been continually prompted to entry into deep blue waters. The international community is becoming more and more fierce in the competition for ocean fishery resources. It is an important way to expand the cultivation area and improve the production output of sea products by carrying out deep sea aquaculture on a large scale of the fish species that can bring good economic benefits with high quality water resources in the deep waters. With a review and comparison of the successful cases and a focus on the transportation depression and excessive transport fleet in the present day, a technical research to transform a 300,000 DWT ore carrier to an aquaculture vessel was carried out by means of the previous successful experiences in this paper: remolding the hull structure, planning  aquaculture program and designing the matched fish allocation system, deep seawater temperature measurement and drainage system, feeding system, sewage disposal and water renewal system, catching system, etc. in deep waters, summarizing the problems to be solved, thus to promote the applicability, replicability and propagability of deep sea aquaculture and provide reference for the construction of deep blue fishery strategy.