In order to solve the problems of heavy manual labor intensity and backward orientation technology in the pre-treatment stage of thick shell mussels, a new vibration orientation device for thick shell mussels was designed. Firstly, the barycenter position of the thick shell mussel was calculated by using the three-point force measurement method; combined with the vibration theory, the force of the thick shell mussel was analyzed and the movement path was obtained; then kinematics analysis was carried out by Adams software; finally, the main parameters of the directional device were tested by the control variable method. The results showed that when the initial posture of the mussel was head down and abdomen right, the vibration motor frequency was 28.6 Hz and the vibration mesa inclination was 14 °, the success rate of head and tail orientation was 90%, and the average time taken for head and tail orientation was 25 s. The research shows, the device could be effectively connected with other automatic processing equipment of thick shell mussels, improve the degree of automation, reduce the processing personnel allocation, and provide a reference for directional test analysis of other shellfish.