In order to improve the timing, quantitative accuracy and water-saving effect of feeding and waste discharge in fish culture, and reduce labor intensity, a new type of PLC, auger feeding mechanism, geared motor, spreader, liquid level sensor, flow generator, electric valve and automatic dual-channel waste discharge device were adopted. By referring to the artificial culture process, a set of fish culture system integrating automatic feeding and waste discharge was designed and developed. The system has a volume of 1.57m³ and a suitable culture density below 23kg/m³. The equipment performance test and fish culture experiment were carried out on the system. The results showed that the system can automatically adjust the water flow before feeding and automatically discharge the waste after automatic feeding. The feeding capacity of the feeder is 0.3kg/min. The feed amount error is within ±0.5g, and the spreading uniformity is high. The average weight gain of the three generations of Acipenser dabryanus cultured by this system in 2018 increased by 35.56% compared with that of the fish cultured by traditional flowing water, and the feed conversion ratio was reduced by 26.28%. The coefficient of variation of the weight at the beginning and end of culture dropped by 31.46%; the operation process does not require manual participation, the effect of waste collection and discharge is not significantly different from that of large-scale water exchange, and water saving is 90%. The system runs stably during the test.