Copper alloy netting has natural bacteriostasis and corrosion resistance to make up for the shortcomings of traditional netting. However, due to the assembly corners, the local stress concentration of copper alloy netting structure will be caused, thus reducing its fatigue performance. Aiming at the fatigue damage and failure problem of copper alloy netting structure, its ultimate strength and fatigue performance are studied by test method. The fatigue life and failure modes of copper wire and copper alloy netting structure under different loads are analyzed, and the respective fatigue life S-N curves are drawn. Meanwhile, considering the influence of machining corners and assembly process, the stress concentration factor caused by machining corners is analyzed numerically, and the fatigue performance of copper alloy netting structure is re-evaluated by notch stress method. The results show that the fatigue strength of the copper alloy netting structure considering the influence of machining corners only accounts for 6% of the ultimate strength. Reasonable corner machining and assembly process is an effective means to improve the fatigue strength of the copper alloy netting structure.