The production cost and cost components of epinephelus spp. cultured in recirculating aquaculture system(RAS) were analyzed in this paper. The production cost and cost components of pearl gentian epinephelus spp. was estimated based on the typical RAS aquaculture process, supporting facilities, the empirical production data and expenditure of fish farmer in Northern China at per unit area yield of 30 kg/m2、40 kg/m2 and survival rate of 60%、70%、80%. Per unit area yield and survival rate have significant effects on the production costs. As the per unit area yield is 30kg/m and survival rate is 60%, the production cost is 55.6yuan/kg; while the per unit area yield is 40 kg/m2and survival rate is 80%, the production cost is reduced to 45yuan/kg. Fry cost, feedstuff cost, worker salary, power consumption, and depreciation cost are the main cost components of epinephelus spp., which account for 88%-90% of the total cost. Survival rate influences fry cost. As survival rate increases from 60% to 80%, the fry cost is reduced to 9.385yuan/kg from 12.5yuan/kg. Per unit area yield influences sharing costs such as worker salary, power consumption, depreciation, management, disease prevention, liquid oxygen. As the per unit area yield increases from 30kg/m2 to 40kg/m2, the sharing cost is reduced to 22.48yuan/kg from 29.9 yuan/kg. This paper provides reference for the production cost control of epinephelus spp. cultured in RAS system in Northern China.