Through integration of seawater fish farming, biochemical treatment, facilities engineering, environmental engineering, electrical automation, water quality monitoring and other technologies, a set of industrial recirculating aquaculture system for Epinephelus suitable for Guangxi was established. Processing order of the aquaculture system was fish pond, settling pond, protein separator, biological filter, floating system of Sesuvium portulacastrum and ultraviolet sterilization treatment. Biological filter included A, B and C channels, where coral stone was selected as primary and secondary biological filtration in A and B channels and biochemical ball as tertiary filtration. In C channel, coral stone was selected as primary filtration and coconut shell shiver was selected as secondary and tertiary filtration. The results showed that the mass concentration of COD, NH4+-N, NO2--N, NO3--N and PO43- in fish ponds could be significantly reduced by the treatment of settling pond (P < 0.05). The mass concentration of NO3--N in the floating system of Sesuvium portulacastrum was significantly lower than that in the settling pond, protein separator treatment pond, biological filter A and B channels (P < 0.05). In general, the water quality in channel C was slightly lower than channel A and channel B, but the difference was not significant (P > 0.05). The results of this study can provide reliable scientific data and technical support for the development of recirculating aquaculture technology and the transformation of aquaculture mode along the coast of Guangxi.