To solve the problems of high labor intensity and poor cleaning effect of traditional cleaning methods of mussels, a mussel high-pressure water jet cleaning platform was built. Firstly, high pressure water jet cleaning experiment was carried out on a mussel shell with jet pressure, target distance, and incident Angle as variables and jet impact force and jet impact pressure as evaluation indexes. Then, the multi-factor combination experiment is designed by Design-Expert software, and the mathematical model of jet impact force and jet impact pressure were established. The optimal combination of mussel high-pressure water jet cleaning parameters was obtained by using the Box-Behnken response surface; Finally, the optimized cleaning parameters are used for jet cleaning experiments to verify the effectiveness of the parameters. The results show that when the fan nozzles with a jet angle of 65 ° and an inner diameter of 2 mm are used for high-pressure water jet cleaning, the jet impact pressure is 0.011 MPa when the jet pressure is 9.66 MPa, the target distance is 99.88 mm and the incident angle is 75.38°. The jet impact pressure is far less than the pressure bearing capacity of the overall surface of the shell. The cleaned mussel watch case is complete without cracks, and all kinds of stubborn dirt attached to the watch case are basically removed. The cleaning effect is significantly improved compared with the traditional cleaning method. The application of high-pressure water jet technology in mussel cleaning can effectively improve the cleaning degree of the mussel source and the level of industrial fine treatment. At the same time, it also has a certain reference significance for the cleaning of other bivalves.