为验证斑石鲷陆海接力养殖模式的可行性，将工厂化循环水培育的大规格斑石鲷 (350.6±24.3) g，转运投放至莱州湾开放海域大型工程化围栏，开展陆海接力养殖试验，并与同期工厂化循环水养殖斑石鲷进行了为期120 d的对比试验，统计分析斑石鲷的生长特性、血清非特异性免疫指标和抗氧化酶活性以及养殖经济效益。结果显示：经120 d的工厂化循环水养殖后，斑石鲷的平均体质量增长至 (547.6±25.2) g，存活率为95.8%；陆海接力养殖的斑石鲷平均体质量增长至 (735.7±27.9) g，存活率为98.3%，平均体质量和存活率比工厂化循环水养殖分别高34.3%和2.6%。经过陆海接力养殖的斑石鲷其血清溶菌酶(LZS)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶(CAT)的活性都显著高于工厂化循环水养殖（P<0.05），分别提高了40.5%，43.2%，42.3%和39.8%。此外，陆海接力养殖的净利润比工厂化循环水养殖高38.37%。综上，大规格斑石鲷经过大型工程化围栏陆海接力养殖生长性状、免疫力、抗氧化状态和经济效益都得到了提高，相关结果为斑石鲷陆海接力养殖提供理论依据和技术支撑。

 The growth, survival rate, serum immunity and antioxidant enzymes, and economic benefits of Oplegnathus punctatus (350.6 ± 24.3 g) reared in recirculating aquaculture system and offshore aquaculture net pen were investigated to evaluate the technical feasibility of the land-sea alternate mariculture model for Spotted knifejaw, Oplegnathus punctatus. Results showed that the average individual weight of Oplegnathus punctatus reached (547.6 ± 25.2) g and the survival rates reached 95.8 % in the recirculating aquaculture system, while the average individual weight of Oplegnathus punctatus reached (735.7 ± 27.9) g and the survival rates reached 98.3 % in land-sea alternate aquaculture after 120 days culture. The contents of serum lysozyme (LZS), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in land-sea alternate aquaculture were significantly higher than those in recirculating aquaculture system (P< 0.05), 40.5%, 43.2%, 42.3%, and 39.8%, respectively. In addition, the net profit of land-sea alternate aquaculture was 128.34% higher than that of recirculating aquaculture. The results indicated that the optimal growth performance, strong immunity, antioxidant activities and high economic benefits of Oplegnathus punctatus were obtained under the land-sea alternate aquaculture model, which provides the theoretical basis and data support for land-sea alternate aquaculture of Oplegnathus punctatus.