底内底栖生物用于环境监测、生物修复时，为判断过氧化物歧化酶（SOD）活性用作生物指示物反映环境状况的适宜性，以海沙模拟生态毒理学模式生物双齿围沙蚕（Perinereis aibuhitensis）的生境，设计均匀试验并将双齿围沙蚕暴露于不同污染水平的重金属-营养盐-石油烃复合污染15 d，研究其SOD活性在有沉积物时的变化特征。结果显示，各个处理间双齿围沙蚕的SOD活性差异不显著；重金属、营养盐和石油烃均不能显著影响双齿围沙蚕的SOD活性；双齿围沙蚕的SOD活性和污染物之间不存在显著的剂量-毒性效应关系；双齿围沙蚕的SOD活性服从Logistic分布，SOD活性对复合污染的响应不确定。因此，SOD活性能否用于反演环境条件值得商榷；底内底栖生物用作生物监测/生物修复种时，应慎重使用SOD活性反映环境状况。

 To judge suitability of SOD (Superoxide Dismutase) activity used as one biological indicator to reflect environmental conditions if buried type benthos is used for environmental monitoring or bioremediation, the following uniform experiments were conducted. Rag-worms (Perinereis aibuhitensis), one species of model organisms of ecological toxicology, were exposed to different concentration levels of multiple-contamination of heavy metals, nutrients and petroleum hydrocarbon for 15 days, during which inhabits of rag-worms were simulated by sands and SOD activity were measured. There was no significant difference of SOD activity of rag-worm under different treatments. SOD activity couldn’t be significantly influenced by heavy metals, nutrients and petroleum hydrocarbon. There was no dose-toxicity relation between SOD activity and contaminants. Responses of SOD activity to multiple-contamination were uncertain and SOD activity obeyed Logistic distribution. Thus, whether the SOD activity can be used for the inversion of environmental conditions should be deliberated. As buried type benthos is used for environmental monitoring and bioremediation, it should be cautious to select SOD activity as biological indicator to reflect the environmental conditions .